Bold longevity research. Fast.
34M USD deployed for aging science and clinical trials
~1% of donations spent on overhead
3 weeks average time from submission to decision
Impetus Grants provides funding for scientists to start working on what they consider the most important problems in aging biology, without delay. Such work should not be held up by red tape: we offer grants of up to $500k, with decisions made within 3 weeks. Our review process asks "what's the potential for impact" rather than "could this go wrong".
Our goal is to have a broad impact on the field, by supporting projects that challenge assumptions, develop new tools and methodologies, discover new ways to reverse aging processes, and/or synthesize isolated manifestations of aging into a systemic perspective. To ensure that we learn from every project, we’re organizing a special issue of GeroScience to provide an opportunity to publish both positive and negative results from funded studies.
Round 3 is now closed.
Highlights: Impetus-funded projects
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Modular, programmable RNA sensing using ADAR editing in living cells
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Evidence that conserved essential genes are enriched for pro-longevity factors
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Could aging evolve as a pathogen control strategy?
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Optogenetic rejuvenation of mitochondrial membrane potential extends C. elegans lifespan
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University of Washington Rapamycin Study
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Epigenetic profiling and incidence of disrupted development point to gastrulation as aging ground zero in Xenopus laevis
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Aging Fly Cell Atlas Identifies Exhaustive Aging Features at Cellular Resolution
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Genetic perturbation of mitochondrial function reveals functional role for specific mitonuclear genes, metabolites and pathways that regulate lifespan
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![Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes]()
Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes
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![Evaluation of off-label rapamycin use to promote healthspan in 333 adults]()
Evaluation of off-label rapamycin use to promote healthspan in 333 adults
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Predictive Modeling of Single-Cell Multiomics Over Time and Space
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Systems Age: A single blood methylation test to quantify aging heterogeneity across 11 physiological systems
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![Massively parallel in vivo Perturb-seq reveals cell-type-specific transcriptional networks in cortical development]()
Massively parallel in vivo Perturb-seq reveals cell-type-specific transcriptional networks in cortical development
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Macrophage-fibroblast crosstalk drives Arg1-dependent lung fibrosis via ornithine loading
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Cytosolic and mitochondrial tRNA synthetase inhibitors increase lifespan in a GCN4/atf-4-dependent manner
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Induction of proteasomal activity in mammalian cells by lifespan-extending tRNA synthetase inhibitors
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Multiomics of GCN4-Dependent Replicative Lifespan Extension Models Reveals Gcn4 as a Regulator of Protein Turnover in Yeast
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Robust genome and cell engineering via in vitro and in situ circularized RNAs
People behind Impetus Grants
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Lada Nuzhna
Program co-founder. Program director.
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Dr Martin Borch Jensen
Program co-founder. Reviewer. Founder of Gordian.
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Juan Benet
Program co-founder. Donor. Founder of Protocol Labs.
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Robert Rosenkranz
Donor. Chairman of Delphi Capital Management.
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Hevolution Foundation
Donor
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Dr Adam Freund
Core reviewer
Founder of Arda Therapeutics
Ex-Calico
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Dr Matt Kaeberlein
Core reviewer
Founder of Ora Biomedical, Dog Aging Project
Professor at University of Washington
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Vitalik Buterin
Donor. Creator of Ethereum.
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Fred Ehrsam
Donor. Founder of Coinbase.
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Michael Antonov
Donor. Founder of Oculus VR and Formic Ventures.
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James Fickel
Donor. Longevity investor and philantropist.
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Jed McCaleb
Donor. Founder of startups Vast, Stellar, and Ripple.
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Karl Pfleger
Donor. Longevity investor and philanthropist.
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Molly Mackinlay
Donor.
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Feruell
Donor